Research and Publications

Research and Publications

The Alder Hey diabetes team is actively involved in research into improving the care and treatment of diabetes.

You may be asked if you would like to participate in one of our ongoing research projects.

Each project is slightly different – some involve devices such as insulin pumps and pens or glucose sensors; others involve questionnaires to assess how we can support you with your diabetes management. If you decide to participate in a project it will be explained to you fully before you start. 

 

Our recent projects include:

Research project

Aims

Active / Closed

Open to

Investigators

PUGS

The study aims to evaluate the accuracy of the existing Freestyle Libre device when its use is extended from 14 to 21 days.

Active

10 patients aged 4 to 17 years old

Principal investigator:

Dr Mark Deakin

Co-invesigators:

Dr Princy Paul

Dr Fulya Mehta

Dr Atrayee Ghatak

 

 

CLOuD project

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This study aims to find out if Closed Loop technology (using a pump and sensor to automatically adjust insulin doses) can preserve the function of insulin producing cells in young people who have recently been diagnosed with type 1 diabetes better than multiple daily injections.

 

We are hoping to find out if Closed Loop therapy could be considered as a standard treatment in the future by comparing results from the Closed Loop system to results from usual therapy.

Active

Up to 100 young people aged from 10-16 years old will be included in the trial.

 

Half of the young people enrolled in the study will use Closed Loop technology, and half will continue with multiple daily injections.

 

Principal Investigator:

Dr Atrayee Ghatak

 

Co-Investigator:

Dr Princy Paul

 

Co-Investigator:

Dr Fulya Mehta

 

Co-Investigator:

Dr Mark Deakin

 

 

ADDRESS 2

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This project is designed to look at the characteristics of people newly diagnosed with type 1 with diabetes in the UK.

It involves collecting information about their diabetes, and also agreeing to be contacted about other opportunities to take part in type 1 diabetes research.
We are looking for siblings to help too.

 

Active

Newly diagnosed with Type 1 diabetes in the last 6 months.

Aged 5 years or older

Principal Investigator:

Dr Princy Paul

 

Co-Investigator:

Dr Atrayee Ghatak

 

 

AWARD-PEDS

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(H9X-MC-GBGC)

 

This study is looking at the benefit of once weekly Dulaglutide for children with Type 2 Diabetes.

The study lasts for one year and uses a double blind crossover design. Some patients will receive a placebo medication and then swap onto the study medication after 6 months.

Active

Type 2 diabetes with inadequate control despite dietary and exercise advice.

Aged 10-18 years old.

Principal Investigator:

Dr Princy Paul

 

Co-Investigator:

Dr Fulya Mehta

 

TRIAL NET

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This study gives the opportunities for our patients and their relatives to be part of an international trial working towards prevention of type1 diabetes in high risk individuals using oral insulin.

Active

Children with Type 1 diabetes and their siblings.

Principal Investigator:

Dr Princy Paul

 

Co-Investigator:

Dr Atrayee Ghatak

 

 

SCIPI Trial

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The study was designed to find out whether insulin treatment using insulin pumps is more effective than insulin treatment using insulin injections in babies, children and young people who had just been diagnosed with type I diabetes.

Closed

All ages

Chief investigator:

Dr J Blair

 

Principal Investigator:

Dr Atrayee Ghatak

 

Co-Investigator:

Dr Princy Paul

 

 

Publications

UK service level audit of insulin pump therapy in paediatrics. Ghatak A, Paul P, Hawcutt DB, White HD, Furlong NJ, Saunders S, Morrison G, Langridge P, Weston PJ. Diabet Med. 2015 Apr 17. doi: 10.1111/dme.12782. [Epub ahead of print]

 

The U.K. service level audit of insulin pump therapy in adults. White HD, Goenka N, Furlong NJ, Saunders S, Morrison G, Langridge P, Paul P, Ghatak A, Weston PJ. Diabet Med. 2014 Apr; 31(4):412-8. Epub 2013 Nov 8.

 

Advanced Nutrition and Dietetics in Diabetes edited by Drs Geoff and Dyson;Wiley Blackwell;published in March 2016, Chapters by Princy Paul and Francsca Annan

Is the glycaemic control in type 1 diabetes mellitus affected by Vitamin D status? Donatella Pintus, Dinesh Giri, Supriya Phanse, Fulya Mehta, Atrayee Ghatak, Princy Paul & Senthil Senniappan. Endocrine Abstracts (2015) 39 EP33 | DOI:10.1530/endoabs.39.EP33

 

 Pancreatitis, adrenal insufficiency and autoimmune diabetes mellitus in a girl with probable sarcoidosis. Carley Frerichs, Renuka Ramakrishnan, Hussain Alsaffar, Urmi Das, Poonam Dharmaraj, Eileen Baildam, Gavin Cleary, Liza McCann, Suneela Nayak & Senthil Senniappan. Endocrine Abstracts (2015) 39 EP40 | DOI:10.1530/endoabs.39.EP40

 

Are we screening appropriate age groups for early diagnosis of CF Related Diabetes Mellitus? Arundoss Gangadharan, Claire Berry, Ruth Watling, Sue Kerr, Kevin Sothern, Senthil Senniappan (RCPCH Oral, Liverpool 2016)

 

Design and trial of basal rate adjustment tool in children and young people receiving insulin pump therapy. Mark Deakin, Francesca Annan, Fulya Mehta, Atrayee Ghatak, Princy Paul; Diabetic Medicine,33(Suppl. 1),35,107



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